A case of pulmonary hemorrhage due to drug-induced pneumonitis secondary to ticagrelor therapy

Chest. 2014 Mar 1;145(3):639-641. doi: 10.1378/chest.13-1502.

Abstract

We report a case of significant pulmonary hemorrhage developing shortly after commencing ticagrelor and aspirin therapy and requiring coronary artery bypass grafting to safely cease the antiplatelet therapy. Lung biopsy findings were consistent with drug-induced lung injury. Clinicians should be aware of this significant adverse event with this drug class.

Publication types

  • Case Reports

MeSH terms

  • Acute Coronary Syndrome / therapy*
  • Adenosine / adverse effects
  • Adenosine / analogs & derivatives*
  • Adenosine / therapeutic use
  • Aspirin / adverse effects
  • Aspirin / therapeutic use
  • Biopsy
  • Coronary Artery Bypass
  • Diagnosis, Differential
  • Hemoptysis / diagnosis
  • Hemoptysis / etiology*
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Pneumonia / chemically induced*
  • Pneumonia / complications
  • Pneumonia / diagnosis
  • Purinergic P2Y Receptor Antagonists / adverse effects
  • Purinergic P2Y Receptor Antagonists / therapeutic use
  • Ticagrelor
  • Tomography, X-Ray Computed

Substances

  • Platelet Aggregation Inhibitors
  • Purinergic P2Y Receptor Antagonists
  • Ticagrelor
  • Adenosine
  • Aspirin