Biologically active eremophilane-type sesquiterpenes from Camarops sp., an endophytic fungus isolated from Alibertia macrophylla

J Nat Prod. 2014 Mar 28;77(3):668-72. doi: 10.1021/np400825s. Epub 2014 Mar 4.

Abstract

Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology*
  • Ascomycota / chemistry*
  • Brazil
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Reactive Oxygen Species / antagonists & inhibitors
  • Rubiaceae / microbiology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Trypan Blue

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Reactive Oxygen Species
  • Sesquiterpenes
  • Trypan Blue