The relationships between cardiovascular disease and diabetes: focus on pathogenesis

Jason C Kovacic; Jose M Castellano; Michael E Farkouh; Valentin Fuster

doi:10.1016/j.ecl.2013.09.007

The relationships between cardiovascular disease and diabetes: focus on pathogenesis

Endocrinol Metab Clin North Am. 2014 Mar;43(1):41-57. doi: 10.1016/j.ecl.2013.09.007.

Authors

Jason C Kovacic¹, Jose M Castellano¹, Michael E Farkouh², Valentin Fuster³

Affiliations

¹ Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
² Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Peter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre of Excellence, Cardiovascular Research, University of Toronto, MaRS Building 101 College Street, 3rd Floor, Toronto, ON M5G 1L7, Canada.
³ Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro, 3.Código Postal 28029, Madrid, Spain. Electronic address: valentin.fuster@mountsinai.org.

PMID: 24582091
DOI: 10.1016/j.ecl.2013.09.007

Abstract

There is a looming global epidemic of obesity and diabetes. Of all the end-organ effects caused by diabetes, the cardiovascular system is particularly susceptible to the biologic perturbations caused by this disease, and many patients may die from diabetes-related cardiovascular complications. Substantial progress has been made in understanding the pathobiology of the diabetic vasculature and heart. Clinical studies have illuminated the optimal way to treat patients with cardiovascular manifestations of this disease. This article reviews these aspects of diabetes and the cardiovascular system, broadly classified into diabetic vascular disease, diabetic cardiomyopathy, and the clinical management of the diabetic cardiovascular disease patient.

Keywords: Cardiovascular disease; Diabetes; Diabetic cardiomyopathy; Obesity.

Publication types

Review

MeSH terms

Cardiovascular Diseases* / economics
Cardiovascular Diseases* / etiology
Cardiovascular Diseases* / physiopathology
Cardiovascular Diseases* / prevention & control
Diabetes Complications* / economics
Diabetes Complications* / etiology
Diabetes Complications* / physiopathology
Diabetes Complications* / prevention & control
Diabetes Mellitus* / economics
Diabetes Mellitus* / physiopathology
Diabetes Mellitus* / prevention & control
Humans