Abstract
Instead of rapid multiplication, pathogenic mycobacteria, such as Mycobacterium tuberculosis are likely to have acquired slow but long life. Host immunity affords desirable non-competitive environment for M tuberculosis in human lungs, where this pathogen slowly grows or arrests growing, which avoids rapid loss of living places. Mycobacterial DNA-binding protein 1 (MDP1), a unique histone-like protein associating mycobacterial GC-rich DNA, has pivotal role in realizing such slow life and pathogenesis including drug tolerance to isoniazid.
MeSH terms
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Animals
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Antitubercular Agents / pharmacology*
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Bacterial Physiological Phenomena / genetics*
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Bacterial Proteins / physiology
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DNA-Binding Proteins / physiology
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Drug Resistance, Bacterial / genetics*
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Humans
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Isoniazid / pharmacology*
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Lung / microbiology
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / growth & development*
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Mycobacterium tuberculosis / pathogenicity
Substances
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Antitubercular Agents
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Bacterial Proteins
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DNA-Binding Proteins
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MDP1 protein, Mycobacterium
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Isoniazid