Abstract
An efficient asymmetric synthesis of atorvastatin calcium has been achieved from commercially available diethyl 3-hydroxyglutarate through a novel approach that involves an organocatalytic enantioselective cyclic anhydride desymmetrization to establish C(3) stereogenicity and cyanide-free assembly of C7 amino type side chain via C5+C2 strategy as the key transformations.
MeSH terms
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Anhydrides
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Atorvastatin
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Calcium / chemistry*
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Cyanides / chemistry*
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Glutarates / chemistry*
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Heptanoic Acids / chemical synthesis*
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Heptanoic Acids / chemistry
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / chemical synthesis*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / chemistry
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
Substances
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Anhydrides
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Cyanides
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Glutarates
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Heptanoic Acids
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Pyrroles
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diethyl 3-hydroxyglutarate
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Atorvastatin
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Calcium