Abstract
Plasmid-mediated kanamycin resistance was detected in a strain of Mycobacterium abscessus subsp. bolletii responsible for a nationwide epidemic of surgical infections in Brazil. The plasmid did not influence susceptibility to tobramycin, streptomycin, trimethoprim-sulfamethoxazole, clarithromycin, or ciprofloxacin. Plasmid-mediated drug resistance has not been described so far in mycobacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Typing Techniques / methods
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Brazil
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DNA, Bacterial / genetics
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Drug Resistance / genetics*
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Humans
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Microbial Sensitivity Tests / methods
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Mycobacterium / drug effects
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Mycobacterium / genetics*
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Mycobacterium Infections / drug therapy
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Mycobacterium Infections / microbiology*
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Plasmids / genetics*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial