A new cyclopeptide with antifungal activity from the co-culture broth of two marine mangrove fungi

Nat Prod Res. 2014;28(9):616-21. doi: 10.1080/14786419.2014.887074. Epub 2014 Feb 26.

Abstract

A new cyclic tetrapeptide, cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline) (1), was isolated from the co-culture broth of two mangrove fungi Phomopsis sp. K38 and Alternaria sp. E33. The structure of 1 was determined by analysis of spectroscopic data and Marfey's analytic method. Primary bioassay demonstrated that compound 1 exhibited moderate to high inhibitory activity against four crop-threatening fungi including Gaeumannomyces graminis, Rhizoctonia cerealis, Helminthosporium sativum and Fusarium graminearum as compared with triadimefon.

Keywords: antifungal activity; co-culture; cyclopeptide; mangrove fungi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternaria / chemistry*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Ascomycota / chemistry*
  • Coculture Techniques
  • Fusarium / drug effects
  • Helminthosporium / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology*
  • Rhizoctonia / drug effects
  • Rhizophoraceae / microbiology
  • Triazoles / pharmacology

Substances

  • Antifungal Agents
  • Peptides, Cyclic
  • Triazoles
  • cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline)
  • triadimefon