Abstract
A new cyclic tetrapeptide, cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline) (1), was isolated from the co-culture broth of two mangrove fungi Phomopsis sp. K38 and Alternaria sp. E33. The structure of 1 was determined by analysis of spectroscopic data and Marfey's analytic method. Primary bioassay demonstrated that compound 1 exhibited moderate to high inhibitory activity against four crop-threatening fungi including Gaeumannomyces graminis, Rhizoctonia cerealis, Helminthosporium sativum and Fusarium graminearum as compared with triadimefon.
Keywords:
antifungal activity; co-culture; cyclopeptide; mangrove fungi.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternaria / chemistry*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Ascomycota / chemistry*
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Coculture Techniques
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Fusarium / drug effects
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Helminthosporium / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology*
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Rhizoctonia / drug effects
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Rhizophoraceae / microbiology
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Triazoles / pharmacology
Substances
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Antifungal Agents
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Peptides, Cyclic
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Triazoles
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cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline)
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triadimefon