Abstract
Two new azachalcones were prepared by both Claisen-Schmidt condensation and a simple environmentally trendy microwave-assisted method. Ten new N-alkyl (C6,8,10,12,14)-substituted azachalconium bromides (3a-e, 4a-e) were prepared from compounds 1 and 2 with corresponding alkyl halides. The antimicrobial activities of all the compounds were tested against Enterococcus faecalis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus micro-organisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Aza Compounds / pharmacology*
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Chalcones / chemical synthesis*
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Chalcones / chemistry
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Chalcones / pharmacology*
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Enterococcus faecalis / drug effects
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Microwaves*
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Yersinia / drug effects
Substances
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Anti-Bacterial Agents
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Aza Compounds
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Chalcones