Abstract
This article reviews recent advances achieved during recent years on various aspects of antibody humanization theories and techniques. Common methods for producing humanized antibodies including framework-homology-based humanization, germline humanization, complementary determining regions (CDR)-homology-based humanization and specificity determining residues (SDR) grafting, as well as advantages and disadvantages of each of these methods and their applications are discussed.
MeSH terms
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Amino Acid Sequence
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Antibodies, Monoclonal, Humanized / chemistry
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Antibodies, Monoclonal, Humanized / classification
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Antibodies, Monoclonal, Humanized / genetics*
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Antibodies, Monoclonal, Humanized / immunology*
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Antibodies, Monoclonal, Humanized / therapeutic use
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Complementarity Determining Regions / immunology*
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Germ Cells / immunology
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Humans
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Protein Engineering / methods*
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Sensitivity and Specificity
Substances
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Antibodies, Monoclonal, Humanized
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Complementarity Determining Regions