Abstract
Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cytochalasin B / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Humans
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Pancreatic Elastase / metabolism
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Spectrum Analysis
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Taiwan
Substances
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Anti-Inflammatory Agents
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Diterpenes
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eunicellin
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krempfielin N
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krempfielin O
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krempfielin P
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Cytochalasin B
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase