This article examines the main household demographics and economic factors associated with food insecurity and coping behavior of rural households employed during times of food shortages in northern Ethiopia. Using a cost-of-basic-needs approach we estimated the food poverty line. This cut-off value was used to classify households as either food secure or insecure. Then empirical analyses were used, based on respectively a logit regression model and a coping strategy index. The estimated results revealed that household size, size of farm land, livestock ownership, frequency of extension services, and proximity to basic infrastructures are associated with the food security status of farming households in the study area. Moreover, households relied largely on consumption-based coping strategies when faced with food shortages.