Coumarinoids from the fruits of Micromelum falcatum

Jittra Suthiwong; Uraiwan Sriphana; Yordhathai Thongsri; Pawantree Promsuwan; Chularut Prariyachatigul; Chavi Yenjai

doi:10.1016/j.fitote.2014.02.004

Coumarinoids from the fruits of Micromelum falcatum

Fitoterapia. 2014 Apr:94:134-41. doi: 10.1016/j.fitote.2014.02.004. Epub 2014 Feb 19.

Authors

Jittra Suthiwong¹, Uraiwan Sriphana², Yordhathai Thongsri³, Pawantree Promsuwan¹, Chularut Prariyachatigul⁴, Chavi Yenjai⁵

Affiliations

¹ Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
² Department of Science and Technology, Faculty of Liberal Arts and Science, Roi-Et Rajabhat University, Selapoom, Roi-Et 45120, Thailand.
³ Department of Medical Technology, Faculty of Allied Health Science, Naresuan University, Phitsanulok 65000, Thailand.
⁴ Department of Microbiology, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University, Khon Kaen 40002, Thailand.
⁵ Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: chayen@kku.ac.th.

PMID: 24561007
DOI: 10.1016/j.fitote.2014.02.004

Abstract

Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.

Keywords: Antifungal; Micromelum falcatum; Pythium insidiosum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology
Coumarins / chemistry*
Coumarins / isolation & purification
Coumarins / pharmacology
Dose-Response Relationship, Drug
Fruit / chemistry
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Pythium / drug effects*
Pythium / growth & development
Rutaceae / chemistry*

Substances

Antifungal Agents
Coumarins
Plant Extracts
coumarin