Dynamic prions revealed by magic

Mick F Tuite; Mark J Howard; Wei-Feng Xue

doi:10.1016/j.chembiol.2014.02.001

Dynamic prions revealed by magic

Chem Biol. 2014 Feb 20;21(2):172-3. doi: 10.1016/j.chembiol.2014.02.001.

Authors

Mick F Tuite¹, Mark J Howard², Wei-Feng Xue³

Affiliations

¹ Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK. Electronic address: m.f.tuite@kent.ac.uk.
² Protein Science Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
³ Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.

PMID: 24560165
DOI: 10.1016/j.chembiol.2014.02.001

Abstract

Prion proteins can be propagated as amyloid fibrils with several different conformational variants. By providing structural information at atomic level for two such variants of a yeast prion, Frederick and colleagues, in this issue of Chemistry & Biology, reveal how conformational flexibility can generate phenotypic diversity.

Publication types

Comment

MeSH terms

Amyloid / metabolism*
Molecular Chaperones / metabolism*
Prions / metabolism*

Substances

Amyloid
Molecular Chaperones
Prions