Lower limb amputations in patients with diabetes are still a huge public health problem. Despite of our knowledge and advanced technical tools, the incidence of amputations and they relapses remain very high and inacceptable. A key role in primary and secondary prevention of amputations is the foot off-loading. We dispose different off-loading devices and techniques which are efficient on short term. However, knowledge about its long term efficacy is missing. In this article, we review different methods of foot off-loading. We also describe a new method for diabetic foot off-loading based on the biofeedback technique we recently developed.