Association of Fas -1377 G/A polymorphism with susceptibility to cancer

Peiliang Geng; Jianjun Li; Juanjuan Ou; Ganfeng Xie; Ning Wang; Lisha Xiang; Rina Sa; Chen Liu; Hongtao Li; Houjie Liang

doi:10.1371/journal.pone.0088748

Association of Fas -1377 G/A polymorphism with susceptibility to cancer

PLoS One. 2014 Feb 18;9(2):e88748. doi: 10.1371/journal.pone.0088748. eCollection 2014.

Authors

Peiliang Geng¹, Jianjun Li¹, Juanjuan Ou¹, Ganfeng Xie¹, Ning Wang¹, Lisha Xiang¹, Rina Sa¹, Chen Liu¹, Hongtao Li¹, Houjie Liang¹

Affiliation

¹ Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China.

Abstract

Background: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants.

Methods: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software.

Results: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06-1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10-1.29, Pheterogeneity= 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04-1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02-1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04-1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians.

Conclusions: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease / genetics*
Humans
Neoplasms / ethnology
Neoplasms / genetics*
Polymorphism, Single Nucleotide*
fas Receptor / genetics*

Substances

FAS protein, human
fas Receptor

Grants and funding

This work was supported in part by grant number 30973430 from the National Natural Science Foundation of China (to HJ.L). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.