Notch and human hematopoietic stem cells

Blood. 2014 Feb 20;123(8):1115-6. doi: 10.1182/blood-2014-01-546754.

Abstract

In this issue of Blood, Benveniste et al report contrasting effects of canonical Notch signaling on human hematopoietic stem cells ex vivo and in vivo. Notch enhanced stem cell expansion in culture, but not in xenogeneic recipients.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Male
  • Multipotent Stem Cells / cytology*
  • Multipotent Stem Cells / metabolism*
  • Receptors, Notch / metabolism*
  • Signal Transduction / physiology*

Substances

  • Receptors, Notch