Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression

PLoS One. 2014 Feb 12;9(2):e88118. doi: 10.1371/journal.pone.0088118. eCollection 2014.

Abstract

Objective: This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk.

Method: The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.

Results: Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms.

Conclusion: The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Cholesterol Ester Transfer Proteins / genetics*
  • Cohort Studies
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Myocardial Infarction / genetics*
  • Polymorphism, Single Nucleotide*
  • Regression Analysis
  • Risk Factors

Substances

  • CETP protein, human
  • Cholesterol Ester Transfer Proteins
  • Genetic Markers

Grants and funding

This work was supported by a grant from the Tianqing Research Foundation (No. TQGB20120101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.