Abstract
Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.
Keywords:
Adamantanes; Antiproliferative activity; Antiviral activity; Phthalimides; Polycyclic compounds; Unnatural amino acids.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adamantane / analogs & derivatives*
-
Adamantane / chemical synthesis*
-
Adamantane / pharmacology
-
Animals
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Antiviral Agents / chemical synthesis*
-
Antiviral Agents / pharmacology
-
Cell Line, Tumor
-
Cell Proliferation / drug effects*
-
Chlorocebus aethiops
-
Cytopathogenic Effect, Viral / drug effects
-
Dogs
-
Drug Design
-
Fibroblasts / drug effects
-
Fibroblasts / virology
-
HeLa Cells
-
Humans
-
Inhibitory Concentration 50
-
Madin Darby Canine Kidney Cells
-
Mice
-
Molecular Structure
-
Small Molecule Libraries / chemical synthesis*
-
Small Molecule Libraries / pharmacology
-
Structure-Activity Relationship
-
T-Lymphocytes / drug effects
-
T-Lymphocytes / virology
-
Vero Cells
-
Viral Plaque Assay
Substances
-
Antineoplastic Agents
-
Antiviral Agents
-
Small Molecule Libraries
-
Adamantane