Antiproliferative and antiviral activity of three libraries of adamantane derivatives

Arch Pharm (Weinheim). 2014 May;347(5):334-40. doi: 10.1002/ardp.201300345. Epub 2014 Feb 13.

Abstract

Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.

Keywords: Adamantanes; Antiproliferative activity; Antiviral activity; Phthalimides; Polycyclic compounds; Unnatural amino acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / chemical synthesis*
  • Adamantane / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Chlorocebus aethiops
  • Cytopathogenic Effect, Viral / drug effects
  • Dogs
  • Drug Design
  • Fibroblasts / drug effects
  • Fibroblasts / virology
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Madin Darby Canine Kidney Cells
  • Mice
  • Molecular Structure
  • Small Molecule Libraries / chemical synthesis*
  • Small Molecule Libraries / pharmacology
  • Structure-Activity Relationship
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / virology
  • Vero Cells
  • Viral Plaque Assay

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Small Molecule Libraries
  • Adamantane