Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells

Abstract

It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a single factor or a complex mixture of factors. In this study it has been shown that, when lung fibroblasts are exposed to dexamethasone, the concentration of neuregulin-1β (NRG1β) in conditioned medium is elevated 2-fold (P<0.05), even though NRG1β gene expression is unaffected. This, together with the finding that exposure of type II cells to NRG1β directly stimulates by 3-fold the rate of phospholipid synthesis (P<0.05), suggests that NRG1β is a component of FPF that promotes lung development.

Keywords: Fibroblast-conditioned media; Neuregulin-1β; Surfactant phospholipid; Type II pneumocyte.