Abstract
In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-α-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism
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Animals
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Cell Differentiation
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Cell Proliferation
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Humans
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Muscle Cells / cytology
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Muscle Contraction
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Muscle, Skeletal / cytology
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiology*
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Receptors, Calcitriol / isolation & purification
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Receptors, Calcitriol / metabolism*
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Vitamin D / metabolism*
Substances
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Receptors, Calcitriol
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Vitamin D
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase