Abstract
No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.
Keywords:
biocatalysis; biosynthesis; enzymes; fluorine; polyketides.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocatalysis
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Biological Products / chemistry
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Biological Products / metabolism*
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Coenzyme A / metabolism
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Fluorine / chemistry*
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Halogenation
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Malonates / chemistry
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Malonates / metabolism
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Polyketide Synthases / metabolism
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Polyketides / chemistry
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Polyketides / metabolism
Substances
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Biological Products
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Malonates
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Polyketides
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Fluorine
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Polyketide Synthases
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malonic acid
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Coenzyme A