Biosynthesis with fluorine

Chembiochem. 2014 Mar 3;15(4):495-7. doi: 10.1002/cbic.201300750. Epub 2014 Feb 6.

Abstract

No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.

Keywords: biocatalysis; biosynthesis; enzymes; fluorine; polyketides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Biological Products / chemistry
  • Biological Products / metabolism*
  • Coenzyme A / metabolism
  • Fluorine / chemistry*
  • Halogenation
  • Malonates / chemistry
  • Malonates / metabolism
  • Polyketide Synthases / metabolism
  • Polyketides / chemistry
  • Polyketides / metabolism

Substances

  • Biological Products
  • Malonates
  • Polyketides
  • Fluorine
  • Polyketide Synthases
  • malonic acid
  • Coenzyme A