Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination

Clin Vaccine Immunol. 2014 Apr;21(4):594-7. doi: 10.1128/CVI.00700-13. Epub 2014 Feb 5.

Abstract

Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Animals
  • BCG Vaccine / administration & dosage*
  • BCG Vaccine / immunology*
  • Colony Count, Microbial
  • Disease Models, Animal
  • Injections, Subcutaneous
  • Lung / immunology
  • Lung / microbiology
  • Mice, Inbred C57BL
  • Mycobacterium tuberculosis / immunology*
  • Spleen / immunology
  • Tuberculosis, Pulmonary / immunology
  • Tuberculosis, Pulmonary / prevention & control*
  • Vaccination / methods*

Substances

  • BCG Vaccine