Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: a meta-analysis

J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):585-92. doi: 10.1177/1470320313507622. Epub 2014 Feb 4.

Abstract

Background: Previous studies examined the association between angiotensin-converting enzyme (ACE) I/D polymorphism and pneumonia, but their results were inconsistent. Thus, a meta-analysis was performed to clarify the effect of ACE I/D polymorphism on pneumonia risk and pneumonia-related mortality.

Methods: The PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI) databases were searched for relevant studies published up to 27 April 2013. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Results: Pooled analysis of 12 case-control studies (1431 cases and 3600 controls) showed that there was a significant association between ACE I/D polymorphism and pneumonia risk in a recessive genetic model (OR = 1.53, 95% CI 1.30-1.80, p < 0.00001). No significant association between ACE I/D polymorphism and mortality was observed (OR = 2.68, 95% CI 0.80-8.90, p = 0.11).

Conclusions: Our meta-analysis confirmed that ACE I/D polymorphism was associated with pneumonia risk. However, ACE I/D polymorphism was not associated with pneumonia mortality.

Keywords: Angiotensin-converting enzyme; association study; mortality; pneumonia; polymorphism.

Publication types

  • Meta-Analysis

MeSH terms

  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Humans
  • INDEL Mutation / genetics*
  • Odds Ratio
  • Peptidyl-Dipeptidase A / genetics*
  • Pneumonia / genetics*
  • Polymorphism, Genetic*
  • Publication Bias
  • Risk Factors

Substances

  • Peptidyl-Dipeptidase A