Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

Cancer Biol Ther. 2014 Mar 1;15(3):256-62. doi: 10.4161/cbt.27823. Epub 2014 Feb 4.

Abstract

Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.

Keywords: DNA damage; Jab1/CSN5; genomic instability; therapeutic approach; tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COP9 Signalosome Complex
  • DNA / metabolism*
  • DNA Damage / physiology*
  • DNA Repair / physiology*
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Peptide Hydrolases / genetics
  • Peptide Hydrolases / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • DNA
  • Peptide Hydrolases
  • COPS5 protein, human
  • COP9 Signalosome Complex