Copper-catalyzed ortho-C-H amination of protected anilines with secondary amines

Chem Commun (Camb). 2014 Mar 14;50(21):2801-3. doi: 10.1039/c3cc49633c.

Abstract

A practical Cu-catalyzed picolinamide-directed o-amination of anilines showing excellent mono-substitution selectivity and high functional group tolerance has been developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Amines / chemistry*
  • Aniline Compounds / chemistry*
  • Carbon / chemistry
  • Catalysis
  • Copper / chemistry*
  • Hydrogen / chemistry

Substances

  • Amines
  • Aniline Compounds
  • Carbon
  • Copper
  • Hydrogen