Abstract
The cornerstone of adult onset Still's disease is the triad of daily fever, arthritis and rash. This syndrome remains enigmatic and most often a disease of exclusion. There are both musculoskeletal as well as systemic features. More importantly, reactive hemophagocytic syndrome may occur in patients. In this review we attempt to place this syndrome in perspective, including data on geoepidemiology, clinical and laboratory features.
Keywords:
Arthritis; Cytokines; Fever; Rash; Still's disease; fever of unknown origin.
Copyright © 2014 Elsevier Ltd. All rights reserved.
MeSH terms
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Arthritis / classification
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Arthritis / diagnosis
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Autoimmune Diseases / classification
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Autoimmune Diseases / diagnosis
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Autoimmune Diseases / immunology
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Bacteremia / classification
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Bacteremia / diagnosis
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Bacteremia / immunology
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Delayed Diagnosis
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Diagnosis, Differential
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Exanthema / classification
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Exanthema / diagnosis
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Fever of Unknown Origin / classification
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Fever of Unknown Origin / diagnosis
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Humans
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Inflammation / classification
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Inflammation / diagnosis
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Inflammation / immunology
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Inflammation / pathology
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Lymphohistiocytosis, Hemophagocytic / classification
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Lymphohistiocytosis, Hemophagocytic / diagnosis
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Lymphohistiocytosis, Hemophagocytic / immunology
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Lymphohistiocytosis, Hemophagocytic / pathology
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Musculoskeletal Abnormalities / classification
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Musculoskeletal Abnormalities / diagnosis
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Musculoskeletal Abnormalities / immunology
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Musculoskeletal Abnormalities / pathology
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Retrospective Studies
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Still's Disease, Adult-Onset / classification*
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Still's Disease, Adult-Onset / diagnosis*
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Still's Disease, Adult-Onset / immunology
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Still's Disease, Adult-Onset / pathology
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Virus Diseases / classification
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Virus Diseases / diagnosis
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Virus Diseases / immunology