Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Sung Hoon Baik; Moon-Yong Cha; Young-Min Hyun; Hansang Cho; Bashar Hamza; Dong Kyu Kim; Sun-Ho Han; Heesun Choi; Kyung Ho Kim; Minho Moon; Jeewoo Lee; Minsoo Kim; Daniel Irimia; Inhee Mook-Jung

doi:10.1016/j.neurobiolaging.2014.01.003

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Neurobiol Aging. 2014 Jun;35(6):1286-92. doi: 10.1016/j.neurobiolaging.2014.01.003. Epub 2014 Jan 8.

Authors

Affiliations

¹ Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
² Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
³ BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea.
⁵ Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
⁶ Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea. Electronic address: inhee@snu.ac.kr.

PMID: 24485508
PMCID: PMC4248665
DOI: 10.1016/j.neurobiolaging.2014.01.003

Abstract

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

Keywords: Alzheimer's disease; Amyloid plaques; Immune cells; Neutrophils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / immunology*
Animals
Brain / immunology*
Cell Movement / immunology*
Cells, Cultured
Disease Models, Animal
Humans
Mice
Mice, Transgenic
Microscopy / methods
Molecular Imaging / methods
Neutrophils / immunology*
Plaque, Amyloid / immunology*

Abstract

Publication types

MeSH terms

Grants and funding