Effect of immunotherapy on the response of TICLs to solid tumour invasion

Math Biosci. 2014 Mar:249:52-9. doi: 10.1016/j.mbs.2014.01.002. Epub 2014 Jan 27.

Abstract

There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction of TICLs with tumour cells, with and without clinical intervention. Stability analysis and numerical simulations of the models reveal the existence of a stable tumour dormant state.

Keywords: Cancer dormancy; Immunotherapy; Resting cells; Tumour-immune interactioné TICLs-tumour interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Humans
  • Immunotherapy*
  • Interleukin-2 / metabolism
  • Lymphocytes, Tumor-Infiltrating / classification
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Lymphocytes, Tumor-Infiltrating / pathology
  • Mathematical Concepts
  • Models, Immunological*
  • Neoplasm Invasiveness / immunology*
  • Neoplasm Invasiveness / pathology
  • Neoplasms / blood supply
  • Neoplasms / immunology
  • Neoplasms / therapy

Substances

  • IL2 protein, human
  • Interleukin-2