Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Heli Venhoranta; Shun Li; Sylwia Salamon; Tatiana Flisikowska; Magnus Andersson; Marek Switonski; Alexander Kind; Angelika Schnieke; Krzysztof Flisikowski

doi:10.1016/j.bbrc.2014.01.071

Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Biochem Biophys Res Commun. 2014 Feb 14;444(3):391-4. doi: 10.1016/j.bbrc.2014.01.071. Epub 2014 Jan 27.

Authors

Heli Venhoranta¹, Shun Li², Sylwia Salamon³, Tatiana Flisikowska², Magnus Andersson¹, Marek Switonski³, Alexander Kind², Angelika Schnieke², Krzysztof Flisikowski⁴

Affiliations

¹ Department of Production Animal Medicine, University of Helsinki, Saarentaus, Finland.
² Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
³ Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland.
⁴ Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany. Electronic address: flisikowski@wzw.tum.de.

PMID: 24480436
DOI: 10.1016/j.bbrc.2014.01.071

Abstract

The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3' end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.

Keywords: Epigenetic regulation; Intrauterine growth restriction; Mammalian DNA; Non-CpG methylation; PEG3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Cattle
CpG Islands*
DNA Methylation*
DNA Primers
Female
Fetal Growth Retardation / metabolism*
Mutation*
Placenta / metabolism*
Polymerase Chain Reaction
Pregnancy

Substances

DNA Primers