Novel dinorcassane- and cassane-type diterpenes from the seeds of Caesalpinia minax

Fitoterapia. 2014 Apr:94:172-6. doi: 10.1016/j.fitote.2014.01.021. Epub 2014 Jan 27.

Abstract

Two novel diterpenes, norcaesalpinin I (1) featuring an unusual ring C-contracted dinorcassane and caesalpinin U (2) possessing a highly oxygenated furanocassane skeleton were isolated from the seeds of Caesalpinia minax. Their structures were determined by different spectroscopic methods. A plausible biosynthetic pathway of 1 was proposed. The cytotoxic activity of compounds 1 and 2 against HepG2 and HeLa human tumor cell lines was evaluated.

Keywords: Biosynthetic pathway; Caesalpinia minax; Cytotoxic activity; Norcassane diterpene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosynthetic Pathways
  • Caesalpinia / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plants, Medicinal
  • Seeds / chemistry

Substances

  • Diterpenes
  • Plant Extracts
  • caesalpinin U
  • norcaesalpinin I