Association of inconclusive sera for human immunodeficiency virus infection with malaria and Epstein-Barr virus infection in Central Africa

Francois-Xavier Mbopi-Keou; Angélique Ndjoyi-Mbiguino; Frédéric Talla; Hélène Péré; Khady Kebe; Mathieu Matta; Maurice Aurelien Sosso; Laurent Bélec

doi:10.1128/JCM.02945-13

Association of inconclusive sera for human immunodeficiency virus infection with malaria and Epstein-Barr virus infection in Central Africa

J Clin Microbiol. 2014 Feb;52(2):660-2. doi: 10.1128/JCM.02945-13. Epub 2013 Dec 4.

Authors

Francois-Xavier Mbopi-Keou¹, Angélique Ndjoyi-Mbiguino, Frédéric Talla, Hélène Péré, Khady Kebe, Mathieu Matta, Maurice Aurelien Sosso, Laurent Bélec

Affiliation

¹ The University of Yaoundé I, Yaoundé, Cameroon.

Abstract

Among 464 sera from adults in Cameroon, 56 (12.1%) gave inconclusive HIV serology. All were negative for HIV-1 DNA; 44.6% (n = 25) were significantly associated with Plasmodium (42.8%) or Epstein-Barr virus (EBV) (17.8%) infections. In Central Africa, sera giving inconclusive results for HIV are frequently associated with malaria, EBV infection, or both.

MeSH terms

Adult
Cameroon
Diagnostic Errors*
Epstein-Barr Virus Infections / complications*
HIV Infections / complications*
HIV Infections / diagnosis*
Humans
Malaria / complications*
Serologic Tests / methods