Acrodermatitis continua of Hallopeau (ACH), a variant of pustular psoriasis, chiefly affects distal parts of the hands and feet (1,2). Arthritis occasionally occurs in psoriasis, including pustular psoriasis, as psoriatic arthritis (3), but it is uncommon in ACH. Here, we report on two cases of ACH with arthritis that was improved by infliximab together with methotrexate as well as salazosulfapyridine. As arthritis is refractory to conventional therapies, our cases could provide a clue to clarifying therapies for ACH.