HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient

Chem Res Toxicol. 2014 Feb 17;27(2):175-7. doi: 10.1021/tx400460w. Epub 2014 Jan 31.

Abstract

HLA-A*31:01 is associated with carbamazepine (CBZ) hypersensitivity in Caucasian and Japanese populations. Herein, we show that HLA-A*31:01+ restricted the activation of carbamazepine-specific CD8(+) T-cells, which provides an immunological basis for the genetic association. Furthermore, CD4(+) T-cells were activated with carbamazepine in a HLA-DRB1*04:04-restricted manner, indicating that a common HLA haplotype may contribute to the multiclonal T-cell response seen in European patients with CBZ hypersensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Presenting Cells / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Carbamazepine / adverse effects*
  • Clone Cells / immunology
  • Drug Hypersensitivity / immunology*
  • HLA-A Antigens / immunology*
  • Humans

Substances

  • HLA-A Antigens
  • HLA-A31 antigen
  • Carbamazepine