A mild Ni/Cu-catalyzed silylation via C-O cleavage

Cayetana Zarate; Ruben Martin

doi:10.1021/ja412107b

A mild Ni/Cu-catalyzed silylation via C-O cleavage

J Am Chem Soc. 2014 Feb 12;136(6):2236-9. doi: 10.1021/ja412107b. Epub 2014 Feb 3.

Authors

Cayetana Zarate¹, Ruben Martin

Affiliation

¹ Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007, Tarragona, Spain.

PMID: 24476124
DOI: 10.1021/ja412107b

Abstract

A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.