Six new tetraprenylated alkaloids from the South China Sea gorgonian Echinogorgia pseudossapo

Mar Drugs. 2014 Jan 27;12(2):672-81. doi: 10.3390/md12020672.

Abstract

Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC₅₀ values of 8.5 and 20.3 µM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
  • Alkaloids / administration & dosage
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Animals
  • Anthozoa / chemistry*
  • China
  • Cyclic Nucleotide Phosphodiesterases, Type 4 / drug effects
  • Cyclic Nucleotide Phosphodiesterases, Type 5 / drug effects
  • Inhibitory Concentration 50
  • Oceans and Seas
  • Phosphodiesterase Inhibitors / administration & dosage
  • Phosphodiesterase Inhibitors / isolation & purification
  • Phosphodiesterase Inhibitors / pharmacology*
  • Spectrum Analysis

Substances

  • Alkaloids
  • Phosphodiesterase Inhibitors
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Cyclic Nucleotide Phosphodiesterases, Type 5