PCBs and ADHD in Mohawk adolescents

Neurotoxicol Teratol. 2014 Mar-Apr:42:25-34. doi: 10.1016/j.ntt.2014.01.005. Epub 2014 Jan 21.

Abstract

The present study examines the relationship between the levels of persistent polychlorinated biphenyls (PCBs) in adolescents' blood serum and concurrent measures of their ADHD-like behavior derived from ratings provided by parents and teachers. Two measures with demonstrated diagnostic validity, the Conners and ADDES scales, are used. The study was conducted in partnership with the Mohawk Nation at Akwesasne where the St. Lawrence River and surrounding waterways have been contaminated with PCBs that have entered the food chain. This study examines a subset of the data derived from the Mohawk Adolescent Well-Being Study (MAWBS), which was designed to investigate psychosocial and health related outcomes of 271 adolescents aged 10 years to 17 years and whose mothers were likely to have consumed PCB-contaminated fish and wild game before and during their pregnancy. No evidence of negative effects of adolescent blood PCB levels on ADHD-like behavior was found, and indeed occasional findings were in the unexpected direction. The possibility of negative confounding by SES and breastfeeding history was examined but dismissed.

Keywords: ADHD; Adolescents; Native American; Polychlorinated biphenyls (PCBs).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adolescent Behavior / drug effects
  • Adolescent Behavior / psychology
  • Attention Deficit Disorder with Hyperactivity / blood
  • Attention Deficit Disorder with Hyperactivity / chemically induced*
  • Body Burden
  • Breast Feeding / adverse effects
  • Child
  • Child Behavior / drug effects
  • Child Behavior / psychology
  • Environmental Exposure
  • Environmental Pollutants / blood
  • Environmental Pollutants / toxicity*
  • Female
  • Food Contamination
  • Humans
  • Indians, North American / psychology*
  • Male
  • New York
  • Polychlorinated Biphenyls / blood
  • Polychlorinated Biphenyls / toxicity*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / blood
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Prenatal Exposure Delayed Effects / psychology*
  • Risk Factors

Substances

  • Environmental Pollutants
  • Polychlorinated Biphenyls