Bioactive phthalides from Ligusticum sinense Oliv cv. Chaxiong

Fitoterapia. 2014 Mar:93:226-32. doi: 10.1016/j.fitote.2014.01.010. Epub 2014 Jan 20.

Abstract

Five new phthalides (1-4, 6), two new natural products (5, 7) and five known phthalides (8-12) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were established by the circular dichroism (CD) spectrum and the modified Mosher's method. Compounds 1-8 were tested against SK-N-SH cell depriving oxygen and glucose and showed different degrees of increasing the cell survival, among which compounds 1, 4 and 8 (10 μM) showed higher cell survival than Ginsenoside Rg1.

Keywords: Aerial parts; CD; Ligusticum sinense Oliv cv. Chaxiong; Modified Mosher's method; Neuronal impairment protective effect; Phthalide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Cell Line
  • Humans
  • Ligusticum / chemistry*
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification*

Substances

  • Benzofurans
  • Neuroprotective Agents