Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging

Satoshi Okada; Shin Mizukami; Takao Sakata; Yutaka Matsumura; Yoshichika Yoshioka; Kazuya Kikuchi

doi:10.1002/adma.201305018

Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging

Adv Mater. 2014 May 21;26(19):2989-92. doi: 10.1002/adma.201305018. Epub 2014 Jan 22.

Authors

Satoshi Okada¹, Shin Mizukami, Takao Sakata, Yutaka Matsumura, Yoshichika Yoshioka, Kazuya Kikuchi

Affiliation

¹ Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

PMID: 24453039
DOI: 10.1002/adma.201305018

Abstract

Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core-shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity (r2 ), but not in longitudinal relaxivity (r1 ). Quantitative pH imaging is achieved by measuring the r2 /r1 value with a clinical 3 T MRI scanner.

Keywords: contrast agents; core-shell nanoparticles; magnetic resonance imaging; pH-responsive polymers; ratiometric sensors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemistry*
Coordination Complexes / chemistry
Gadolinium / chemistry
Hydrogen-Ion Concentration
Magnetic Resonance Imaging*
Magnetics
Nanoparticles / chemistry*
Polymers / chemistry

Substances

Contrast Media
Coordination Complexes
Polymers
Gadolinium