Abstract
P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
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Animals
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / therapeutic use
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Bacteria / chemistry
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Biological Products / pharmacology*
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Cyanobacteria / chemistry
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Drug Resistance, Multiple / drug effects
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Drug Resistance, Neoplasm / drug effects
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Humans
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Porifera / physiology
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Seawater / microbiology
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Urochordata / physiology
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents
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Biological Products