Severe acute renal failure in patients treated with glucagon-like peptide-1 receptor agonists

D Dubois-Laforgue; D Boutboul; D J Lévy; D Joly; J Timsit

doi:10.1016/j.diabres.2013.11.014

Severe acute renal failure in patients treated with glucagon-like peptide-1 receptor agonists

Diabetes Res Clin Pract. 2014 Mar;103(3):e53-5. doi: 10.1016/j.diabres.2013.11.014. Epub 2013 Nov 20.

Authors

D Dubois-Laforgue¹, D Boutboul², D J Lévy², D Joly³, J Timsit²

Affiliations

¹ Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: daniele.dubois@cch.aphp.fr.
² Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
³ Department of Nephrology, Hôpital Necker, 149 rue de Sèvres, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

PMID: 24447807
DOI: 10.1016/j.diabres.2013.11.014

Abstract

We report two patients with diabetes in whom acute renal failure requiring hemodialysis occurred while on treatment with glucagon-like peptide-1 receptor agonists. We discuss the mechanisms of this complication and the potential for its prevention.

Keywords: Acute interstitial nephritis; Acute renal failure; Exenatide; Glucagon-like peptide-1 receptor agonists; Liraglutide; Type 2 diabetes mellitus.

Publication types

Case Reports

MeSH terms

Acute Kidney Injury / chemically induced*
Acute Kidney Injury / therapy
Aged
Diabetes Mellitus, Type 2 / drug therapy*
Female
Glucagon-Like Peptide 1 / adverse effects*
Glucagon-Like Peptide-1 Receptor
Humans
Hypoglycemic Agents / adverse effects*
Male
Middle Aged
Prognosis
Receptors, Glucagon / agonists*
Renal Dialysis

Substances

GLP1R protein, human
Glucagon-Like Peptide-1 Receptor
Hypoglycemic Agents
Receptors, Glucagon
Glucagon-Like Peptide 1