A synergistic combination therapy with paclitaxel and doxorubicin loaded micellar nanoparticles

Colloids Surf B Biointerfaces. 2014 Apr 1:116:41-8. doi: 10.1016/j.colsurfb.2013.12.051. Epub 2013 Dec 30.

Abstract

Doxorubicin was chemically conjugated to a biodegradable polymeric carrier as a polymer-doxorubicin (polymer-Dox) conjugate via an acid labile Schiff-base bond. Then, paclitaxel was physically encapsulated by the polymer-Dox conjugate to self assemble in water as micellar nanoparticles with both doxorubicin and paclitaxel in one nanoparticle. In this way, doxorubicin and paclitaxel were combined. The preparation of the polymer-doxorubicin conjugates, encapsulation of paclitaxel, characterization of nanoparticles was systematically studied and the biological evaluation of the free drug combination as well as the micellar platform combination in vitro was thoroughly detailed.

Keywords: Combination therapy; Doxorubicin; Drug delivery; Nanoparticles; Paclitaxel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / chemical synthesis
  • Antineoplastic Combined Chemotherapy Protocols / chemistry
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Screening Assays, Antitumor
  • Hep G2 Cells
  • Humans
  • MCF-7 Cells
  • Micelles*
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacology*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Micelles
  • Doxorubicin
  • Paclitaxel