Abstract
One new inositol triester, 4,5,6-tri-O-p-hydroxyphenylacetyl-chiro-inositol (1), was isolated from the ethanolic extract of Taraxacum mongolicum, along with two known compounds, 11β,13-dihydrotaraxinic acid (2) and taraxinic acid β-d-glucopyranosyl ester (3). The isolates were tested for their anti-hepatitis B virus (HBV) activities; 11β,13-dihydrotaraxinic acid (2) exhibited an IC50 value of 0.91 mM inhibiting the secretion of the HBV surface antigen and an IC50 value of 0.34 mM inhibiting the secretion of the HBV e antigen using HBV transfected Hep G2.2.15 cell line.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Hep G2 Cells
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Hepatitis B virus / drug effects
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Hepatitis B virus / immunology
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Humans
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Inhibitory Concentration 50
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Inositol / analogs & derivatives*
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Inositol / chemistry
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Inositol / isolation & purification*
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Inositol / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Taraxacum / chemistry*
Substances
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11beta,13-dihydrotaraxinic acid
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4,5,6-tri-O-p-hydroxyphenylacetyl-chiro-inositol
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Antiviral Agents
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Drugs, Chinese Herbal
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Sesquiterpenes
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Inositol