Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogels

Adv Mater. 2014 Jan 22;26(3):436-42. doi: 10.1002/adma.201303387. Epub 2013 Oct 22.

Abstract

Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications.

Keywords: biocompatibility; glycosaminoglycans; hydrogels; proteoglycans; toughness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry
  • Animals
  • Biocompatible Materials / chemistry*
  • Biomedical Engineering / methods
  • Biopolymers / chemistry
  • Cartilage / chemistry
  • Cells, Cultured
  • Chondroitin Sulfate Proteoglycans / chemistry*
  • Chondroitin Sulfates / chemistry*
  • Decapodiformes
  • Elastic Modulus
  • Humans
  • Hyaluronic Acid / chemistry*
  • Hydrogels / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Molecular Weight
  • Osmotic Pressure
  • Polymers / chemistry*
  • Salmon
  • Streptococcus equi
  • Tensile Strength

Substances

  • Acrylamides
  • Biocompatible Materials
  • Biopolymers
  • Chondroitin Sulfate Proteoglycans
  • Hydrogels
  • Polymers
  • Hyaluronic Acid
  • Chondroitin Sulfates
  • N,N-dimethylacrylamide