Abstract
Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications.
Keywords:
biocompatibility; glycosaminoglycans; hydrogels; proteoglycans; toughness.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry
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Animals
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Biocompatible Materials / chemistry*
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Biomedical Engineering / methods
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Biopolymers / chemistry
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Cartilage / chemistry
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Cells, Cultured
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Chondroitin Sulfate Proteoglycans / chemistry*
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Chondroitin Sulfates / chemistry*
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Decapodiformes
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Elastic Modulus
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Humans
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Hyaluronic Acid / chemistry*
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Hydrogels / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Molecular Weight
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Osmotic Pressure
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Polymers / chemistry*
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Salmon
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Streptococcus equi
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Tensile Strength
Substances
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Acrylamides
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Biocompatible Materials
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Biopolymers
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Chondroitin Sulfate Proteoglycans
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Hydrogels
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Polymers
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Hyaluronic Acid
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Chondroitin Sulfates
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N,N-dimethylacrylamide