Idiopathic aplastic anemia: diagnosis and classification

Osnat Jarchowsky Dolberg; Yair Levy

doi:10.1016/j.autrev.2014.01.014

Idiopathic aplastic anemia: diagnosis and classification

Autoimmun Rev. 2014 Apr-May;13(4-5):569-73. doi: 10.1016/j.autrev.2014.01.014. Epub 2014 Jan 12.

Authors

Osnat Jarchowsky Dolberg¹, Yair Levy²

Affiliations

¹ Hematology Unit, Meir Medical Center, Kfar-Saba, Israel.
² Department of Medicine 'E', Meir Medical Center, Kfar-Saba, Israel. Electronic address: levy.yair@clalit.org.il.

PMID: 24424170
DOI: 10.1016/j.autrev.2014.01.014

Abstract

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.

Keywords: Aplastic anemia; Autoimmunity; Immunosuppressive therapy; Pancytopenia.

Publication types

Review

MeSH terms

Anemia, Aplastic / diagnosis*
Anemia, Aplastic / drug therapy
Anemia, Aplastic / epidemiology
Anemia, Aplastic / metabolism
Animals
Autoantibodies / immunology
Hematopoietic Stem Cell Transplantation / adverse effects
Humans
Immunosuppressive Agents / therapeutic use
T-Lymphocytes / immunology
Telomere / genetics

Substances

Autoantibodies
Immunosuppressive Agents

Supplementary concepts

Aplastic anemia, idiopathic