Antimicrobial activity of cationic gemini surfactant containing an oxycarbonyl group in the lipophilic portion against gram-positive and gram-negative microorganisms

J Oleo Sci. 2014;63(2):137-40. doi: 10.5650/jos.ess13089. Epub 2014 Jan 14.

Abstract

We evaluated the antimicrobial activities of a cationic Gemini surfactant, trans-1,4-bis[2-(alkanoyloxy)ethyldimethylammonio]-2-butene dichloride [II-m-2(t-butene)] and its derivatives against Gram-positive and Gram-negative microorganisms. The II-m-2(t-butene) compound was previously shown to have good surface activity and biodegradability. A dodecanoyloxy derivative (m = 12) of II-m-2(t-butene) showed excellent antimicrobial activity against Gram-positive Streptococcus aureus [minimum inhibitory concentration (MIC): 7.8 μg/mL] and Gram-negative Escherichia coli (MIC: 31.2 μg/mL).

MeSH terms

  • Alkenes / chemistry
  • Alkenes / pharmacology*
  • Anti-Bacterial Agents*
  • Biotransformation
  • Calcitriol / analogs & derivatives*
  • Calcitriol / chemistry
  • Calcitriol / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects*
  • Molecular Conformation
  • Staphylococcus aureus / drug effects*
  • Surface-Active Agents / chemistry*
  • Surface-Active Agents / pharmacology*

Substances

  • 1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)
  • Alkenes
  • Anti-Bacterial Agents
  • Surface-Active Agents
  • Calcitriol
  • 2-butene