The infection caused by the human T-cell lymphotropic virus type 1 (HTLV-1) (HTLV-I) has a worldwide distribution. This condition has a worldwide distribution and now it is spreading towards non-endemic areas and it is becoming a public health problem. It is not unusual to see patients with HTLV-1 coinfected with Strongyloides stercoralis and presenting with digestive manifestations, but it is less frequent to find the additional occurrence of other pathogens leading to bacterial infections and multiple onychomycosis. We present the case of a 34-year old man with all those coinfections with peripheral vascular involvement. Some aspects of HTLV-1 pathogenesis are discussed, emphasizing the presence of this virus and the other associated pathogens, and we suggest that tests for determining the presence of HTLV-1 infection may be requested in such cases.