Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum

Qi-Chang Zheng; Ming-Zhu Kong; Qin Zhao; Guo-Dong Chen; Hai-Yan Tian; Xiao-Xia Li; Liang-Dong Guo; Jia Li; Yi-Zhi Zheng; Hao Gao

doi:10.1016/j.fitote.2013.12.022

Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum

Fitoterapia. 2014 Mar:93:126-31. doi: 10.1016/j.fitote.2013.12.022. Epub 2014 Jan 11.

Authors

Qi-Chang Zheng¹, Ming-Zhu Kong², Qin Zhao¹, Guo-Dong Chen³, Hai-Yan Tian¹, Xiao-Xia Li¹, Liang-Dong Guo⁴, Jia Li⁵, Yi-Zhi Zheng², Hao Gao⁶

Affiliations

¹ Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
² Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.
³ Department of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510642, PR China. Electronic address: chgdtong@163.com.
⁴ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
⁵ National Center for Drug Screening, and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203, PR China.
⁶ Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tghao@jnu.edu.cn.

PMID: 24418656
DOI: 10.1016/j.fitote.2013.12.022

Abstract

Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control.

Keywords: Chaetoglobosins; Chaetomiaceae; Chaetomium globosum; Cytochalasans; Cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / analysis
Chaetomium / chemistry*
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Molecular Structure

Substances

Antineoplastic Agents
Indole Alkaloids
chaetoglobosins