Risk assessment is a decision-making tool used by the U.S. Environmental Protection Agency and other governmental organizations to organize and analyze scientific information so as to examine, characterize, and possibly quantify threats to human health and/or ecologic resources. Sustainability evaluation is a process for organizing and analyzing scientific and technical information about nature-society interactions in order to help decision-makers determine whether taking or avoiding certain actions will make society more sustainable. Although development and application of these two methodologies have progressed along distinct and unconnected pathways, the National Research Council recently recommended that the U.S. Environmental Protection Agency adopt the concept of "sustainability" as both a process and a goal, and that risk assessment be incorporated, when appropriate, as a key input into decision-making about sustainability. The following discussion briefly reviews these two analytic approaches and examines conceptual frameworks for integrating assessments of risk and sustainability as a component of regulatory decision-making.