Study on biodegradation of the second phase Mg17Al12 in Mg-Al-Zn alloys: in vitro experiment and thermodynamic calculation

Chen Liu; Huazhe Yang; Peng Wan; Kehong Wang; Lili Tan; Ke Yang

doi:10.1016/j.msec.2013.10.020

Study on biodegradation of the second phase Mg17Al12 in Mg-Al-Zn alloys: in vitro experiment and thermodynamic calculation

Mater Sci Eng C Mater Biol Appl. 2014 Feb 1:35:1-7. doi: 10.1016/j.msec.2013.10.020. Epub 2013 Oct 31.

Authors

Chen Liu¹, Huazhe Yang², Peng Wan³, Kehong Wang⁴, Lili Tan⁵, Ke Yang⁶

Affiliations

¹ Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
² Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China; Department of Biophysics, China Medical University, Shenyang 110001, China.
³ Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
⁴ Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
⁵ Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China. Electronic address: lltan@imr.ac.cn.
⁶ Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China. Electronic address: kyang@imr.ac.cn.

PMID: 24411344
DOI: 10.1016/j.msec.2013.10.020

Abstract

The in vitro biodegradation behavior of Mg17Al12 as a second phase in Mg-Al-Zn alloys was investigated via electrochemical measurement and immersion test. The Hank's solutions with neutral and acidic pH values were adopted as electrolytes to simulate the in vivo environment during normal and inflammatory response process. Furthermore, the local orbital density functional theory approach was employed to study the thermodynamical stability of Mg17Al12 phase. All the results proved the occurrence of pitting corrosion process with crackings for Mg17Al12 phase in Hank's solution, but with a much lower degradation rate compared with both AZ31 alloy and pure magnesium. Furthermore, a preliminary explanation on the biodegradation behaviors of Mg17Al12 phase was proposed.

Keywords: Biodegradation; Magnesium alloy; Mg(17)Al(12) phase; Thermodynamical stability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorbable Implants*
Alloys / chemistry
Aluminum / chemistry*
Biocompatible Materials / chemistry*
Body Fluids / chemistry*
Computer Simulation
Energy Transfer
Magnesium / chemistry*
Materials Testing
Models, Chemical*
Molecular Conformation
Phase Transition
Surface Properties
Thermodynamics
Zinc / chemistry*

Substances

Alloys
Biocompatible Materials
Aluminum
Magnesium
Zinc