Fast gradient-encoded CEST spectroscopy of hyperpolarized xenon

Jörg Döpfert; Christopher Witte; Leif Schröder

doi:10.1002/cphc.201300888

Fast gradient-encoded CEST spectroscopy of hyperpolarized xenon

Chemphyschem. 2014 Feb 3;15(2):261-4. doi: 10.1002/cphc.201300888. Epub 2014 Jan 10.

Authors

Jörg Döpfert¹, Christopher Witte, Leif Schröder

Affiliation

¹ Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin (Germany).

PMID: 24408772
DOI: 10.1002/cphc.201300888

Abstract

Breaking speed limits: The acquisition of xenon-129 Hyper-CEST spectra is drastically accelerated by utilizing gradients to encode the chemical shift dimension. The signal is increased by using repeated spin-echo refocussing. The additional application of a variable flip angle makes the experiment independent from a constant Xe redelivery.

Keywords: cest agents; hyper-cest; hyperpolarized xenon; nmr spectroscopy; ultrafast gradient encoding.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemistry
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy*
Polycyclic Compounds / chemistry
Xenon / chemistry*

Substances

Contrast Media
Polycyclic Compounds
cryptophane A
Xenon